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[DOI] [PMC free article] [PubMed] [Google Scholar] 440.Liu Y., Wang L

It suggested that GD activates Nrf2 signaling pathway to increase HO-1 expression to regulate the expression of related proteins [133]

Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]

Jakubowski and collaborators have recently reported that cells efficiently convert homocysteine into homocysteine thiolactone by methionyl-tRNA synthetase (Jakubowski et al, 2000b)

Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM et al

There are also studies in the literature reporting that these compounds do not show any effect