and 5-TGGCAAATTCCATGGCACC-3 (sense) and 5-AGAGATGATGACCCTTTTG-3 (antisense) to detect GAPDH mRNAs
Platinum-based drugs: cisplatin/Platinol, oxaliplatin/Eloxatin, carboplatin/Paraplatin Taxanes: paclitaxel/Taxol, docetaxel/Taxotere, cabazitaxel/Jevtana Thalidomide and its relatives: carfilzomib/Kyprolis, lenalidomide/Revlimid, pomalidomide/Pomalyst, apremilast/Otezla Epothilones: ixabepilone/Ixempra Proteasome inhibitor: bortezomib/Velcade Vinca alkaloids: vincristine/Marqibo, vinblastine/Velbane The neuropathy caused by most of these drugs commonly shows up weeks or months after treatment has ended
Law GL, Tisoncik-Go J, Korth MJ, Katze MG
Additionally, MRP2 contains a 100-residue long linker between NBD1 and TMD2, resembling the regulatory (R) domain of the cystic fibrosis transmembrane regulator (CFTR)
Incubation of acetone with homogenates of nasal mucosa from mice indicated that acetone was metabolized via a NADPH-dependent pathway in vitro , but no evidence of in vivo metabolism of acetone by the upper respiratory tract was found in mice, rats, guinea-pigs or hamsters (Morris, 1991 )
Outside the CNS, serotonin is produced in the ENS and released predominantly by enterochromaffin cells (estimated to be up to 90% of the body's serotonin production [169]) of the gut mucosa and immune cells, with influence not only on the ENS but also on the CNS via the GBA [283]
