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Further, the colloidal stability of the formulation in circulation and membrane destabilization and hexagonal phase II conversion following exposure to the acidic TME due to the presence of DOPE (37.5%) in the liposome membrane could contribute to the enhanced Dox release within the tumor tissue 17

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NRF2 regulates GSH biosynthesis and related metabolic enzymes, including GCL, GSS, and SLC7A11, all of which are indispensable for GSH synthesis (111)

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To maintain optimal levels of glutathione, the body relies on a recycling process that converts oxidized glutathione back into its reduced form