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350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

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Notably, STING-based immunotherapy was most effective when combined with anti-VEGFR2 and/or ICIs (either anti-PD-1 or anti-CTLA-4), leading to the complete regression of tumors that are resistant to either anti-angiogenic monotherapy or ICI monotherapy

Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin 1 2 3 4 5 6 7 8 Present Knowledge in Nutrition, Eleventh Edition