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Consequently, we delve into the molecular mechanisms through which 16-OHE promotes PH, encompassing induction of oxidative stress, enhancement of proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) and pulmonary arterial endothelial cells (PAECs), promotion of metabolic abnormalities, induction of endothelial mesenchymal transition (EndoMT), and fostering inflammation (Fig

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The DMSs were then categorized based on their location within the gene body according to the reference genome obtained from the UCSC, 40% of DMSs were found within introns, 36% within intergenic regions, 13% in exons, and 11% within promoters