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Plots of colony forming units per mouse lung (log 10 scale) for mice infected with either WT Mtb (black), the glpQ 1 strain (red)

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The reason stacking raises safety questions is simple: when you combine signals, you can also combine side effects, sensitivities, and unintended downstream effects

From the modified Noyes-Whitney equation 2.4, it is clear that larger the surface area, higher the dissolution rate