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Two reviewers independently screened titles and abstracts for inclusion, with conflicts resolved by a third reviewer

Vitamin C topical products are widely available at various price points

SMARCA4 is a protein present in ATP-dependent chromatin remodeling complexes of the SWI/SNF type

Tai et al

Although vitamin C is absorbed from the gut via a sodium-dependent vitamin C transporter, most cells transport vitamin C in an oxidized form (dehydroascorbic acid) via glucose transporter 1

In a retrospective review of 64 patients with metastatic melanoma treated with Nivolumab plus Ipilimumab, 31 patients experienced early toxicity warranting discontinuation of treatment, and 4 of these (13%) further developed a significant irAEs 4 months after treatment cessation