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10.1001/archneurol.2010.168 93 LynchD

Rubinstein WS, Pacanowski M (2021) Pharmacogenetic gene-drug associations: FDA perspective on what physicians need to know

Results OAG patients demonstrated significantly higher GSSG levels and a lower redox index than the controls (p = 0.01, p = 0.01, respectively), but total GSH and reduced GSH levels were similar in the OAG subjects and controls (p = 0.80, p = 0.94, respectively)

Cognitive function also declines with age (Liu, Aging has been associated to a more oxidized state in the redox balance (Jones and Sies, 2013), defined as an unbalanced redox signaling, related to increased amounts of oxidants and ineffective antioxidant defenses (Go and Jones, 2013)