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However, the efficacy of individual antioxidants is quite limited, suggesting that antioxidants are more suitable as adjunctive treatments, further prompting us to consider whether oxidative stress imbalance is a cause or a consequence of neurodegenerative diseases

Generally, Group I mGluRs carry activating G s or G 11 subunits, are localized postsynaptically, and lead to cell depolarization and increased neuronal excitability

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The process of lipid peroxidation has been recognized as a free radical-mediated and physiologically occurring with the supporting evidence of in situ organ chemiluminescence (Boveris et al., 1980)