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A judgment regarding the risk of bias arising from each domain is generated by an algorithm, based on answers to the signaling questions which includes high risk of bias, low risk of bias, or some concerns

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[34] A synthesis of the Cholesterol Lowering Atherosclerosis Study and the Monitored Atherosclerosis Regression Study (MARS) concluded that lipid lowering can halt progression and produce angiographically detectable regression, while emphasizing that the absolute changes in lumen diameter are small relative to the accompanying reduction in clinical events