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The liver has the major responsibility for detoxification, and GSH is the cornerstone of this process

17 Pharmacological ablation of astrocytes in the medial prefrontal cortex (mPFC) causes depressive-like symptoms in experimental animals, 18 and postmortem studies of patients with MDD have shown reduced densities of glial cells in the prefrontal cortex (PFC), hippocampus and amygdala

Steber C., Bezirkskrankenhaus Augsburg, Department of Psychiatry and Psychotherapy

The other four genes GCLC , GHL , G6PD , and 6PGD showed reverse changes in both groups, being upregulated 1.874.13-fold after 2 days

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