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The concept is that patients could achieve significant weight loss on higher doses and then step down to 4mg to maintain results with fewer side effects

doi: 10.1111/j.1365-2249.2004.02566.x 74 ZengYZhangYChenQHuangQLinYWangXet al

Immunity 46, 405420

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Obesity represents itself as a challenge for hypothalamus-pituitary-thyroid axis since it has been hypothesized that hyperleptinemia, that often characterizes these patients, may increase the expression of TRH gene and thus TSH secretion [194]