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The phenolic hydroxyl group of E2, particularly on the A-ring, acts as a direct free radical scavenger by donating hydrogen atoms to neutralize ROS, thereby exerting non-enzymatic antioxidant effects (118)

171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB)

Owing to the origin of the raw materials, the medicinal components, the growth years of the medicinal materials, and the extraction technique, the purity, composition (e.g., polysaccharide content), and chemical structure of APS will vary (Li et al., 2015)

Moreover, the use of GST 4QN as a tag reduced fused p53 aggregation and enhanced the induction of p21 transcription and apoptosis in cells treated with 5-fluorouracil (5-FU)

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