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[DOI] [PMC free article] [PubMed] [Google Scholar] 413.Cancer Genome Atlas Research Network (2014) Integrated genomic characterization of PTC

The underlying mechanisms most likely involve the reduction of ERS-induced apoptosis by suppressing CHOP expression

Possible symptoms include: Brain zaps or electric shock sensations, often triggered by movement or eye shifts Increased sensitivity to light or sound, making environments feel overwhelming Tremors or internal shaking, especially during rest Tingling sensations or restlessness, particularly in the limbs Balance disturbances, sometimes described as feeling like walking on a boat These sensations reflect temporary sensory misfiring during withdrawal and typically fade as neural communication stabilizes over time

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This phenomenon is probably connected with the formation of a molecule-stabilizing open-ring form of midazolam which outweighs a closed-ring form in highly acidic medium (Andersin and Tammilehto 1995)