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FUNDING This work was supported by the by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2023R1A2C2003479), the Bio&Medical Technology Development Program of the NRF funded by the MSIT (NRF-2019M3E5D3073102), and the Basic Science Research Program funded by the Ministry of Education (NRF-2020R1I1A1A01071665 and RS-2023-00248873)

Do not take during pregnancy and in children or otherwise for prolonged periods without seeking medical advice

These mutations disrupt iron homeostasis by phosphorylating Rab8a, leading to the sequestration of Tf within lysosomes and potentially promoting iron accumulation and ferroptosis

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Acknowledgements The authors wish to acknowledge grant support from the German Research Foundation (DFG), Clinical Research Unit KFO 181, projects 1 (STE 892/9-2) and 6 (SCHA 1531/1-1)