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Description

In mouse studies, researchers reported improved health markers rather than obvious toxicity, but mouse safety does not predict human safety

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The success of interventions targeting microglia in the retina or optic nerve head to reduce neurodegeneration underscores the need for early intervention (144146)

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Blood 115 , 965974 (2010)

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Additionally, alternative pyroptosis pathways exist

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CIB1 ) in both alpha and beta cells, with CIB1 protecting against cytokine-induced apoptosis while regulating beta cell identity

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doi: 10.1038/s41408-021-00500-9 195 Rodrguez-ArbolEOthusMOrvainCZarlingLCSandmaierBMMilanoFet al

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