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In addition, dendrimerSIN conjugates were demonstrated to selectively target activated microglia/macrophages in a rabbit model of pediatric traumatic brain injury, where they significantly attenuated acute neuroinflammation and oxidative stress compared with the free drug (150)

This suggests dietary SAAR may increase serine synthesis, in part, by lowering lysine lactoylation

Alongside these trial failures, other major challenges in developing novel IPF therapies include inadequate animal models, insufficient interventions targeting epithelial repair, and a limited understanding of how cellular senescence contributes to fibrosis (Mora et al., 2017)

Gene list comparisons and Venn diagrams were created using BioVenn web tool (Hulsen et al, 2008)

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