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Nerve guidance conduits can restrain trophic molecules released from the distal nerve stump 22 and facilitate ingrowth of Schwann cells 23 and thereby support the regrowth of axons from the proximal nerve stump toward the endoneuroal sheaths within the distal stump, along which the regenerating axons finally reach and reinnervate motor or sensory targets 21

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doi: 10.1038/s41575020-00360-x 13 SiesH