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Furthermore, silk fibroin itself exhibits therapeutic effects, such as attenuating spatial learning and memory impairments and preventing neuronal damage in A 25 35 -induced rat models through the reduction of Tau hyperphosphorylation and suppression of neuroinflammation (Yao et al., 2022), and preventing A- and/or reactive oxygen species-induced inflammation and apoptosis, along with improved cognitive function by increasing acetylcholinesterase ( 4.2.2.4 Dendrimer-based nanoparticles Dendrimers are highly branched macromolecules that consist of a bi- or multifunctional core from which branching units radiate outward

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Solvent A was acetonitrile in 0.1% formic acid, and Solvent B was 0.1% formic acid in ultrapure water