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WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indol e], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity

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They found elevated ROS biomarkers and an AGE-mediated activation of proinflammatory pathways, as indicated by an activation of the AGE-RAGE-NFBp65 pathway in DPN [71]

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Cell swelling and death occur because of the ability of protein pores to facilitate unrestricted interactions with the surrounding environment (Magtanong et al., 2016)