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Nanaomycin A ( 64 ) is an antibiotic that was recently reported to selectively inhibit DNMT3B with an IC 50 of 500 nM, while the activity of DNMT1 was not affected (Figure 10)

Cell cycle-inhibiting chemotherapeutics are widely used in cancer treatment for their ability to curb tumor cell proliferation

SARS-CoV-2 infections are also associated with higher profibrotic dipeptidyl peptidase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK - adenosine monophosphate-activated protein kinase) activation in kidney cells

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At the same time, our study suggests that using antioxidants as an adjuvant therapy strategy, as is done in chronic periodontitis (Castro et al., 2019), may reduce the biochemical changes caused or possibly interfere with the progression of apical periodontitis

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