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One case-control study reported that selenium-responsive glutathione peroxidase 1 (GPx1) activity was significantly lower in Keshan patients compared to healthy individuals

mansoni juvenile worms, the LD 50 of PZQ (413 M) is inferior to that of inhibitors 1 - 5 (7.2 60% reduction in worm burden, a significantly higher efficacy than observed for treatment with PZQ in previous studies 13 , which had 0% reduction at 21 and 28 d.p.i

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Nature 568:230234

Studies with mouse models have shown that hepsin is important for maintaining hepatic structural homeostasis, liver metabolism, and adipocyte browning (Hsu et al