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The IGF family consists mainly of two low-molecular-weight protein (IGF-1 and IGF-2), the corresponding receptors (IGF-1R and IGF-2R) and specific binding proteins (4)

Acute myeloid leukaemia

The drug donepezil, which has the function of AChE inhibitor, can increase ACh in rat hearts and play a long-term protective effect on heart failure (82)

Impaired glucose tolerance is a risk factor for cardiovascular disease but not impaired fasting glucose

Anti-Ageing and DNA Repair NAD+ is a critical cofactor for sirtuins, a family of enzymes that regulate aging and longevity

It was also found that PHD-2 downregulation increased NF-B-mediated expression of IL-8 and angiogenin in certain tumors