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For the third cohort receiving 6 mg/kg DCR-PHXC, the mean maximal 24-h Uox reduction reached 76% (range: 58100%)

T.McCarthyE

If the deficiency goes untreated, severe neurologic effects may develop, so that the deficiency is clinically identified and treated early is very important

VFMC, VG, JT, CS, HE, YYB, CB, MZ, ART and FG designed experiments

(ii) iron-catalyzed auto-oxidation, and (iii) oxidase- and esterase-mediated peroxidation of polyunsaturated fatty acids (PUFA) (Yang and Stockwell, 2016