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Even more remarkably, a 24-week course of 10g daily hydrolyzed collagen actually improved the thickness of articular cartilage in osteoarthritic joints something few interventions can achieve

The observed effects are likely multifactorial, involving redox modulation, anti-inflammatory signaling, and potential endocrine interactions

Finally, early injection of tranexamic acid before admission and during hospitalization can reduce plasma syndecan-1 levels, alleviate endothelial glycocalyx damage, and enhance vascular repair mechanisms [131, 132]

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Splitting doses also dilutes the fasted-state metabolic advantage the evening dose occurs during fed state when insulin is elevated, reducing fat oxidation efficiency