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some strains create fewer or none, others produce more toxic metabolites [31,74]

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EULE treatment elicited a significant upregulation of nsy-1, sek-1 , and pmk-1 mRNA expression ( p 0.05

Cu 2+ functions by binding and regulating growth factors and cell membrane receptors in the extracellular environment, while Cu + exists on the cell membrane and directly regulates kinase activity to alter the activation state of growth factor membrane receptors through structural modification and inhibition of phosphatase function

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Moreover, it is the only candidate drug for ALS to be independently validated by the ALS Therapy Development Institute (Soon et al., 2011)