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10.3389/fphar.2023.1332567 131 LeithnerC.RoylG

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An inflammatory, autoimmune demyelinating disease of the central nervous system in rodents that has high pathological and clinical similarities to human multiple sclerosis and is the most used experimental model for the disease

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In this study, we tested the hypothesis that CHAC1 inhibition may preserve the intracellular glutathione in skeletal muscles and thus represent a novel strategy to treat muscle wasting in cachexia conditions

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For these functions to be balanced, everything must work together, just as a symphony orchestras members must coordinate their actions

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Approximately 100 mg of tissue was then transferred to a 1.5-mL Eppendorf tube, followed by homogenization on ice using an electrical disperser (T 10 basic ULTRA-TURRAX 558 from IKA, equipped with an S10N-5G Dispersing Element) in 1 mL of 2 Sample Buffer (100 mM Tris-HCl, pH 6.8, 4% (m/v) SDS, 20% (v/v) glycerol, and 4% (v/v

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