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Indeed, the downregulation of both miRNAs are linked to the extracellular release of metalloprotease-13 (MMP13), which is inhibited by transient expression of miR-100 and miR-125, also reversing the BC progression by AR [60]

2.3 Cell culture and treatment The human normal hepatic cell line LO2 (Shanghai Institute of Biological Sciences, Chinese Academy of Science, Shanghai, China) was maintained in DMEM(BI,United States) containing 10% FBS (Gibco, United States) and 1% penicillin/streptomycin (Gibco, United States) in a 5% CO2 humidified 37C incubator