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The seminal studies of Schneich (121123) demonstrated that peptides containing a Met residue can form a sulfuranyl free radical (S + ) in the presence of a suitable oxidant

Moreover, macrophage-driven foam cell formation might be increased by the interaction between homocysteine thiolactone and LDL (McCully, 1996

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The exponential escalation of these processes is commonly referred to as a vicious cycle, and the theory predicts that the rise in mtDNA mutations and ROS eventually reach levels that are incompatible with life. It should be noted that whether or not this theory is true for how aging works is contentious