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9IK), while no significant changes in body weight were observed among groups (Fig

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Roflumilast (ROF) has been recognized to have antioxidant and anti-inflammatory activity in in-vivo and in-vitro models

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Influenza Viruses In mice following intranasal infection with a lethal dose of influenza A virus A/PR/8, the use of N-acetylcysteine increased survival rate from 58% (ribavirin monotherapy) to 92% (N-acetylcysteine and ribavirin), suggesting the antioxidants role in improving host defense mechanism and preventing pathogenesis of lung inflammation