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A commenter noted that most REHs operate with scaled-back electronic medical record (EMR) systems that are not designed to capture this data without costly customization and expressed concern that the reporting requirement would risk diverting scarce financial and human resources away from patient care

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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007