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Thus, it might function as Nrf2 agonist [80]

While important mechanistic insights were gained to decipher the glutaredoxin-catalyzed reduction of glutathione disulfide substrates, there are still major gaps in our understanding of the enzyme mechanism regarding the reduction of non-glutathione disulfide substrates

10.1016/j.freeradbiomed.2022.06.004 28 IngoldI.BerndtC.SchmittS.DollS.PoschmannG.BudayK.et al (2018)

doi: 10.1007/s10616-019-00333-2 48

In the initial phase of the study, we concentrated on the binding of BNIP3 and incubated fluorescence-labelled recombinant mBNIP3 with a library of 47 mBNIP3 N-terminal-derived truncated synthetic peptides immobilised on microarrays (Supplementary Table 3)