Can occur with Prolia: serious infections, such as UTIs and skin infections skin side effects, such rash or blisters multiple fractures in your spine after stopping Prolia decreased bone production (when it takes longer for your bones to make new bone tissue) Can occur with Fosamax: irritation in your stomach or intestines, which may lead to ulcers Can occur with both Prolia and Fosamax: severe pain in your joints, bones, or muscles severe allergic reaction dental and jaw-related side effects atypical femur fractures (unusual fractures in your thigh bone) Effectiveness Prolia and Fosamax have different approved uses, but theyre both used to treat osteoporosis in males* and in females* whove gone through menopause
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