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458 Biologics that are used for UC reduce intestinal inflammation by modulating the immune system, and they can inhibit specific inflammatory cytokines, such as tumor necrosis factor and other cytokines, thereby reducing the symptoms and inflammatory response in UC

Dominik Malekinusic, Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb 10 000, Croatia

Although dabigatran is mainly used in patients with cardiovascular disease, atrial fibrillation, or stroke, and the pharmacokinetic and pharmacodynamic properties of the healthy population differ from those of patients, the pharmacokinetic parameters of healthy subjects are more stable and can more clearly reflect the absorption, distribution, metabolism, and excretion characteristics of the drug, thus providing reliable baseline data for subsequent patient studies to validate the efficacy and safety of dabigatran in specific disease states

The practical sequencing rule: use LED before microinfusion or wait 24 hours after

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