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Samples were boiled in a water bath for 10 min before centrifugation at 12,000 g at 20 C for 3 min

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Providing a roadmap for future clinical studies, a larger scale, multi-site trial called TAME (targeting ageing with metformin) aims to enrol 3000 people in the 6579 age range with a primary endpoint of time until age-related morbidity (e.g