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Indians have another issue that is unrelated- systemic Vitamin B12 deficiency

The ALOX12 gene is located on human chromosome 17p13.1, a common location for monoallelic deletions in cancers

We have previously demonstrated a homeostatic imbalance of purine catabolism (Yao et al., 2010b) and blunted platelet serotonergic responsivity (Yao et al., 1996

Sturtz, L.A., Diekert, K., Jensen, L.T., Lill, R

For acute depression-like models, lipopolysaccharide (LPS)induced models are frequently used to mimic inflammationassociated depression in both rats (e.g., Wistar [46]) and mice (e.g., C57BL/6 [47] and ICR [48])