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For severe allergic conditions unresponsive to other treatments, the usual dose is 4-8mg given IM, followed by oral therapy

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Increased NNMT expression has also been reported in muscle-wasting conditions such as Duchenne Muscular Dystrophy (DMD)

This structural difference affects stability, bioavailability, and conversion requirements in the body

doi:10.1016/j.bcp.2017.11.007 PubMed: 29155147 Kraus D, Yang Q, Kong D, et al