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To establish if the binding of Ran to PlexinB1 is dependent on whether Ran is bound to GTP or GDP, pull-down experiments were performed using purified Ran-His protein labelled with GTPS (a non-hydrolysable form of GTP) or GDP

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Regarding drug sources, self-developed drugs had the highest proportion (62.9 %), followed by human-derived substances, antibiotics, and antibodies, collectively accounting for 12.9%

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10.1093/cid/ciu397 4