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Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

doi: 10.1016/j.psychres.2020.113382

By doing so, the present review aims to bridge molecular insights relevant to autoimmune diseases, emphasizing how folate-dependent epigenetic regulation can contribute both to disease-risk stratification and to the development of personalized therapeutic strategies

These results are consistent with the observation that reduction in the dose of PHGDH inhibitor stops further weight loss and suggest that short-term combination treatment does not cause long-term damage