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Its defining pharmacological feature is oral bioavailability unlike the peptide secretagogues that preceded it, MK-677 resists first-pass hepatic degradation and reaches systemic circulation following oral dosing, making it a structurally distinct research tool for studying the GH/IGF-1 axis without parenteral administration

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While treatment with RSL3 alone did not decrease tumour size, treatment with cisplatin reduced mean tumour size (Fig