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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

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A lack of thyroid hormones causes a stressful physiological environment, leading to cortisol and epinephrine secretion via the hypothalamuspituitaryadrenal gland (HPA) axis

Common side effects are mild: Injection site irritation Mild headache Transient flushing Slight appetite changes Serious adverse effects are uncommon with appropriate dosing and medical supervision