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However, teriflunomide and IFN- have limited or no BBB penetrance (187, 188), making it unlikely that these drugs exert continuous, direct effects on CNS-resident cells

Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex

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Modern agonists add fatty-acid chains and amino-acid swaps that resist degradation and bind albumin, stretching the half-life enough for weekly dosing (PMID 31050435)

doi: 10.1155/2022/7273387 184 CaiBGanXHeJHeWQiaoZMaBet al

Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A