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The cellular modulation and protein replacement therapeutic strategies involve mRNAs that encode a functional protein, which can be expressed in the target cell as an endogenous protein, a functional foreign protein or proteins used for gene editing or cellular modulation (Figure 7

292 In RSV-infected airway epithelial cells, NOX-generated ROS trigger the activation of the transcription factors IRF and STAT, thereby inducing the expression of chemokines and cytokines involved in the immune/inflammatory responses of the lung

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Peer-reviewed studies demonstrate that GHK-Cu can: Stimulate fibroblast proliferation and collagen synthesis Increase glycosaminoglycan production Support wound contraction and remodeling Reduce oxidative stress and inflammation A major review published in the International Journal of Molecular Sciences describes GHK-Cu as a compound that resets gene expression to a healthier state, influencing over 4,000 human genes involved in tissue repair and anti-inflammatory processes

BPC 157 reduces various arrhythmias (i.e., potassium overdose-induced hyperkalemia (Barisic et al., 2013), digitalis (Balenovic et al., 2009), neuroleptics (i.e., prolonged QTc-intervals that may also be centrally related) (Strinic et al., 2017), bupivacaine (Zivanovic-Posilovic et al., 2016), lidocaine (Lozic et al., 2020), and succinylcholine (Stambolija et al., 2016))