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We can apply a topical anesthetic beforehand to minimize discomfort, although this is rarely necessary

Of the remaining 45 articles, 6 full texts could not be retrieved and 14 were excluded as they were out of scope

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Int Urogynecol J 34:22072216 Cho SY, Jeong SJ, Lee S, Kim J, Lee SH, Choo MS, Oh SJ (2021) Mirabegron for treatment of overactive bladder symptoms in patients with Parkinsons disease: a double-blind, randomized placebo-controlled trial (Parkinsons Disease Overactive bladder Mirabegron, PaDoMi Study)

[10] 6 injections of 30 nmol/kg over one week , with a one-week follow-up, in 18 chronic psychophysiological insomniacs