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Description

Structure of a human multidrug transporter in an inward-facing conformation

The regulatory machinery is completely different

doi:10.4103/1673-5374.320969

The depletion of tryptophan in the TME impairs effector T cell function, while kynurenine degradation products can suppress tumor immunity by inducing the generation of Foxp3+ regulatory T cells (Tregs) (134)