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A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)

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Was each component quantified separately

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In detail, it has been developed an algorithm predicting antigens able to trigger an immune response in the context of the patients HLA-class I and class II

Lelivre P, Sancey L, Coll JL, Deniaud A, Busser B