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Notably, meta-omics (i.e., the combined application of metagenomics, metatranscriptomics, metaproteomics, and metabolomics to microbial communities) provides deep insights into microbiome-mediated immune signaling in pathologies such as colorectal cancer (174)

Takeuchi O, Akira S

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TNF-, a proinflammatory cytokine, promotes immune cell recruitment and cell death by inducing the expression of cytokines, chemokines, adhesion molecules, cyclooxygenase-2, and inducible nitric oxide synthase or by activating signaling pathways such as the NF-B, STAT, and PPARs pathways

Cancer 130 , 15901597 (2012)

Common side effects include mild pain, swelling, or redness at the injection site