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The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis

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These reactions are catalyzed by lysine acetyltransferase (KAT), and the reverse process is regulated by lysine deacetylase (KDAC), while the acetyl group can add to the amino acid at the N-terminus via N-terminal acetyltransferases (NATs) 114,115

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2.5 Cell death mode The cell death mode in alcohol-related liver disease may involve various types, including pyroptosis, necroptosis, and ferroptosis

For instance, while REW-containing IgG2 is equipped with the capacity to mediate induction of classical complement activation, IgG4 REW remains inert in this regard, which is a differentiator compared to other reported Fc-engineered strategies