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Human Burkitt B lymphocytes require an adequate arginine concentration for proliferation and maturation

Ann Thorac Surg 79(2):391-7

15 It is recommended to initiate at 50% of the usual dose in mild-to-moderate hepatic impairment and avoid use in severe hepatic impairment

van Montfort, R

PubMed Central , Kettunen, Johannes, et al

Opioid-induced esophageal dysfunction (OIED): Cases of OIED have been reported in patients taking opioids, and may occur more frequently in patients taking higher doses of opioid, and/or in patients taking opioids longer term [see WARNINGS]