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This process requires the involvement of protein disulfide isomerase (PDI), ER redox protein 1 (ERO1), and GRP78 chaperone protein

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Indeed, Sp was able to restore cytosolic and mitochondrial redox balance in neuronal cell line SHSY-5Y subjected to 1-methyl-4-phenylpyridinium (MPP + ) treatment which is known to cause mitochondria dysfunction and oxidative stress through complex I inhibition 1 (Fig

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